Cloperastine hydrochloride
Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with an IC 50 value of 27 nM.Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.
Intheanesthetizedguineapigs,Cloperastineatatherapeuticdoseof1 mg/kgprolongedtheQTintervalandmonophasicactionpotential(MAP)durationwi thoutaffectingPRintervalorQRSwidth.Cloperastinehydrochlorideshowsrelat ivelylowacutetoxicChemicalbookitywhenadministeredbytheintraperitonealr outeinratsandmice,an dshowsminortoxicitybytheoralroutewhenadministeredasCloperastinefendizo ate,theLD50inratsandmiceforthetwoadministrationrouteceeds1000and2000mg /kg,respectively.
Brand: Soarwin
CAS：14984-68-0
EC Number: 239-067-8
Molecular Formula: C20H25Cl2NO
Melting point: 147.9°
Contact : Anna Wang, +18 0 99 30 10 07
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