Cloperastine hydrochloride
Details
China Medical
Medical

Cloperastine hydrochloride

Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with an IC 50 value of 27 nM.Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.

Intheanesthetizedguineapigs,Cloperastineatatherapeuticdoseof1 mg/kgprolongedtheQTintervalandmonophasicactionpotential(MAP)durationwi thoutaffectingPRintervalorQRSwidth.Cloperastinehydrochlorideshowsrelat ivelylowacutetoxicChemicalbookitywhenadministeredbytheintraperitonealr outeinratsandmice,an dshowsminortoxicitybytheoralroutewhenadministeredasCloperastinefendizo ate,theLD50inratsandmiceforthetwoadministrationrouteceeds1000and2000mg /kg,respectively.

Brand: Soarwin

CAS：14984-68-0

EC Number: 239-067-8

Molecular Formula: C20H25Cl2NO

Melting point: 147.9°

Location : No. 10-11, Building 4, Zhongyu Duhui First Station, Longxi Street, Yubei District, Chongqing, 401120 chongqing,
Contact : Anna Wang, +18 0 99 30 10 07

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Cloperastine hydrochloride

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