Tamoxifen
Tamoxifen is a nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. It is a Protein Kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines.
In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response mo difiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Brand: Soarwin
CAS No.: 10540-29-1
EC Number: 234-118-0
Molecular Formula: C26H29NO
Density: 1.0630 (rough estimate)
Melting point: 97-98 °C(lit.)
Boiling point: 501.18°C (rough estimate)
Contact : Anna Wang, +18 0 99 30 10 07
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