Raw materials

Octreotide

Octreotide is a digestive system drug, a synthetic octapeptide cyclic compound, a homologue of natural growth inhibitor, with the pharmacological activity of natural growth inhibitor (Somatostatin), and has a long-lasting effect (the half-life of this product is 1.5 hours, while the natural growth inhibitor is 2 to 3 minutes). It has selective inhibitory effect on the secretion of growth hormone, glucagon and insulin, which is stronger than that of natural growth inhibitor. It has been proved by animal experiments that: after 15 minutes of static injection of this product, the inhibitory effect on the release of growth hormone is 70 times as much as that of natural growth inhibitor, and the inhibitory effect on insulin is 3 times as much as that of natural growth inhibitor. It also has inhibitory effect on thyrotropin, adrenocorticotropic hormone, gastrin, cholecystokinin, intestinal vasoactive polypeptide, and can inhibit the secretion of gastric acid, pancreatic amylase, lipase and pepsin. It can slow down the passage time of the gastrointestinal tract, promote the absorption of water and electrolytes, have a constrictive effect on the visceral blood vessels, can reduce visceral blood flow, reduce hepatic blood flow in order to reduce the portal pressure and portal blood flow, reduce intestinal hypersecretion, and can enhance the intestinal absorption of water and Na+. The 1st, 4th and 8th amino acids on the chemical structure Chemicalbook are unnatural amino acids, so they are not easily destroyed by enzymes and have a long half-life. Subcutaneous injection of this product is rapidly and completely absorbed, blood concentration peak time is 0.5 hours, volume of distribution is 0.27L/kg, half-life is 1.5 hours, metabolic clearance is 160ml/min. biphasic elimination is observed when injected, half-life of α-phase and β-phase is 10 minutes and 90 minutes respectively. The plasma protein binding rate is 65%. Clinically octreotide is mainly used for the treatment of esophageal varices out of worms caused by portal hypertension, limb gigantism, gastrointestinal bleeding such as cirrhosis, esophageal variceal bleeding, peptic ulcer bleeding and stress ulcer bleeding, pancreatic diseases such as severe acute pancreatitis, pancreatic injury or post-surgical pancreatic fistula, and prevention of post-surgical complications of the pancreas. It is also used for gastrointestinal fistulas, gastrointestinal endocrine tumors such as intestinal vasoactive peptide tumors, gastrinomas, pancreatic hyperglycemic tumors, ectopic ACTH syndrome, carcinoid syndrome, acromegaly, synucleinopathic hyperthyroidism, persistent, intractable diarrhea that occurs after total colon resection, and AIDS-associated diarrhea. Intrathecal injections are used to treat cancer pain.

Brand: Soarwin

CAS No.: 79517-01-4

EC Number: 616-695-4

Molecular Formula: C51H70N10O12S2

Melting point: 153-156°C

Sotrage: Store at Inert atmosphere,Store in freezer, under -20°C

Location : No. 10-11, Building 4, Zhongyu Duhui First Station, Longxi Street, Yubei District, Chongqing, 401120 chongqing,
Contact : Anna Wang, +18 0 99 30 10 07

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