China Medical
Medical

Linaclotide

Linaclotide is a guanylate cyclase-C receptor agonist (GCCA) with both visceral analgesic effects and endocrine activity. Both linaclotide and its active metabolite bind to guanylate cyclase-C (GC-C) receptors on the luminal surface of small intestinal epithelial tubules. In animal models, linaclotide reduces visceral pain and increases gastrointestinal transit velocity through GC-C activation, and in humans, the drug also increases colonic transit velocity.The result of GC-C activation, i.e., an increase in intracellular and extracellular cGMP (cyclic guanosine monophosphate) concentrations. Extracellular cGMP reduces the activity of painful nerve fibers and can reduce visceral pain in model animals. Intracellular cGMP can increase chloride and bicarbonate secretion in the lumen of the small intestine by activating CFTR (cystic fibrosis transmembrane conductance regulator), which ultimately leads to increased secretion of small intestinal fluid and increased small intestinal transit velocity.

Brand: Soarwin

EC Number: 251-228-4

CAS No.: 851199-59-2

Molecular Formula: C59H79N15O21S6

Melting point: 231-235°C (dec.)

Boiling point: 2045.0±65.0 °C(Predicted)

Density: 1.60

Sotrage: Hygroscopic, Refrigerator, under inert atmosphere

Location : No. 10-11, Building 4, Zhongyu Duhui First Station, Longxi Street, Yubei District, Chongqing, 401120 chongqing,
Contact : Anna Wang, +18 0 99 30 10 07

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Linaclotide

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France 46170 Women clothing
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Thursday, March 20, 2014

Quantity : 300 - Price : 3€

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  • 46170 - L'HOSPITALET
  • +33 6 42 57 86 79
Germany 12345 Sport goods
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Vietnam 10000 Child clothing
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Wednesday, January 20, 2016

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STOCK CLEARANCE: Kids Fashion from 3 to 12 years old - left over stock from S/S 2015 Total stock is 10000pcs to be sold from 45000 Euros. Partial sales under condition, minimum of 2000pcs/order, price to be negotiate. Small series production with approx. 70pcs/ref with over 150 references...

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  • 10000 - Hanoi
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