Hydroxylamine hydrochloride

Hydroxylamine hydrochloride is a white crystalline solid with the chemical formula NH2OH·HCl. It is a salt formed from hydroxylamine and hydrochloric acid, characterized by its strong reducing properties. Hydroxylamine was first synthesized in the 19th century, with its discovery attributed to German chemist Emil Fischer and his colleagues. They described its formation through the reduction of nitrous oxide or the hydrolysis of nitramine compounds. The hydrochloride salt was subsequently produced to enhance its stability and solubility in aqueous solutions, making it a useful reagent in various chemical applications.
Hydroxylamine hydrochloride is primarily employed as a reducing agent in organic synthesis. Its ability to donate electrons makes it invaluable in a range of reactions, particularly in the conversion of carbonyl compounds to their corresponding oximes. The reaction involves the nucleophilic attack of hydroxylamine on the carbonyl carbon, leading to the formation of oximes, which are essential intermediates in the synthesis of various pharmaceuticals, agrochemicals, and fine chemicals. The versatility of hydroxylamine hydrochloride extends to its role in the preparation of hydroxamic acids, which are significant for their bioactivity and applications in drug discovery.

Brand: Soarwin
CAS No.: 5470-11-1
EC number: 226-798-2
Molecular Formula: ClH.H3NO
Density: 1.67g/mLat 25°C(lit.)
Melting point: 155-157°C (dec.)(lit.)
Boiling point: 56.5oC at 760mmHg