(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline can be used to prepare solifenacin. Solifenacin succinate, CAS No. 242478-38-2, chemical name 1-azabicyclo[2.2.2]octan-8-yl-(1S)-1-phenyl-3,4-dihydro-1H-isoquinolin e-2-carboxylate succinate, is prepared by condensing (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline (I) with triphosgene under organic base (weak base) conditions to obtain (S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carbonyl chloride (II). Compound II can be directly heated in the presence of an organic base without separation through a one-pot method, and condensed with (R)-3-quinuclidine to obtain solifenacin (III), which is then salified with succinic acid to obtain solifenacin succinate (IV).
Brand: Soarwin
CAS No.: 118864-75-8
EC Number: 1806241-263-5
Molecular Formula: C15H15N
Density: 1.065
Melting point: 80-82°C
Boiling point: 338°C
Flash point: 167°C
Contact : Shakira Xia, +15 2 82 60 18 74
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