(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinolin
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Raw materials

(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinolin

Quantity : 1kg; 25kg;

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline can be used to prepare solifenacin. Solifenacin succinate, CAS No. 242478-38-2, chemical name 1-azabicyclo[2.2.2]octan-8-yl-(1S)-1-phenyl-3,4-dihydro-1H-isoquinolin e-2-carboxylate succinate, is prepared by condensing (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline (I) with triphosgene under organic base (weak base) conditions to obtain (S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carbonyl chloride (II). Compound II can be directly heated in the presence of an organic base without separation through a one-pot method, and condensed with (R)-3-quinuclidine to obtain solifenacin (III), which is then salified with succinic acid to obtain solifenacin succinate (IV).

Brand: Soarwin

CAS No.: 118864-75-8

EC Number: 1806241-263-5

Molecular Formula: C15H15N

Density: 1.065

Melting point: 80-82°C

Boiling point: 338°C

Flash point: 167°C

Location : Chongqing, 401102 Chongqing,
Contact : Shelley Zhou, +17 7 23 84 28 51

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