SiSiB® PC9235

N,O-Bis trimethylsilyl acetamide

SiSiB® PC9235 (BSA) silane is a colorless to slightly yellowish liquid which is soluble in many nonpolar and polar aprotic solvents.

SiSiB® PC9235, N O bis trimethylsilyl acetamide is an effective silylating agent. It is used in the pharmaceutical and in the chemical industry. Typically the silylating reaction with BSA results in neutral by-products only.

Technical Data

CAS No. 10416 59 8

EINECS No. 233-892-7

Formula C8H21NOSi2

Molecular Weight 203.43

Boiling Point 73°C [35mmHg] 162°C [760mmHg]

Flash Point 42°C

Melting Point 24°C

Color and Appearance Clear to yellowish clear liquid

Density 25/25°C 0.832

Refractive Index 1.418 [25°C]

Min. Purity 98.0%

Application

The trimethylsilyl group is a frequently utilized monofunctional blocking group for protic organic and inorganic materials.

As the product eliminated during the silylation is neutral acetamide, SiSiB® PC9235 can be preferably used for substrates which are acid- or base-sensitive.

SiSiB® PC9235 can be used for blocking and protection of hydroxyl groups in natural products, e.g. amino acids, carbohydrates

SiSiB® PC9235 special silane can be used for blocking and protection of functional groups in organic intermediates.

The silylated derivatives show improved chemical stability than the original compounds and allow chemical reactions which otherwise would not be possible.

SiSiB® PC9235 can be used for formation of derivatives of H-acid compounds for analysis

The silylated derivatives are volatile and can therefore be determined by gas chromatography

Deblocking is preferably carried out by means of hydrolysis, giving high yields. In some cases, thermal elimination of the trimethylsilyl group is possible.

Packing and Storage

SiSiB® PC9235 by SiSiB, a reliable silane mamufacturer, is supplied in 160Kg steel drum.

In the unopened original container SiSiB® PC9235 has a shelf life of one year in a dry and cool place.