Terlipressin acetate API
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Terlipressin acetate API

Terlipressin is a new type of synthetic long-acting vasopressin preparation, belonging to a precursor drug, itself inactive, in vivo by the action of aminopeptidase, to remove its N-terminal 3 glycyl residues, slowly “release” the active lysine pressin. It is this “slow release” mechanism that allows it to maintain smooth muscle contraction for up to 10 hours after a single administration, whereas the activity of vasopressin at the same dose can only be maintained for 20-40 minutes. On the other hand, due to the slow enzymatic release, circulating lysopressin does not reach toxic levels, making terlipressin safe to use. The pharmacological effect of terlipressin is to contract visceral vascular smooth muscle, reduce visceral blood flow (such as reducing the blood flow of mesentery, spleen, uterus, etc.), thus reducing the Chemicalbook portal venous blood flow and lowering the portal pressure, on the other hand, it also reduces the effect of plasma renin concentration, thus increasing the renal blood flow in patients with hepatorenal syndrome and improving the renal function, increasing the urine output. Terlipressin is currently the only drug that can improve the survival rate of patients with ruptured esophageal variceal hemorrhage, previously used in clinical practice mainly for the treatment of ruptured variceal hemorrhage, in addition to this terlipressin has now been successfully used in the hepatic and renal syndrome, and the existence of refractory shock, cardiopulmonary resuscitation is also likely to play a beneficial role. Compared with vasopressin, it is long-lasting, does not cause dangerous complications, including pro-fibrinolysis and serious complications in the cardiovascular system, and is easy to use (can be injected intravenously), which makes it more suitable for the rescue and treatment of patients with acute and critical illnesses.

Brand: Soarwin

EC Number: 238-680-8

CAS No.: 14636-12-5

Molecular Formula: C52H74N16O15S2

Melting point: >170°C (dec.)

Boiling point: 1824.0±65.0 °C(Predicted)

Density: 1.46±0.1 g/cm3(Predicted)

Sotrage: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Location : 重庆渝北, 401000 渝北,
Contact : meng meng, +18 7 23 93 07 08

mengmeng

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Terlipressin acetate API

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